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Richard and colleagues raise important issues regarding the benefit of using combination therapy as well as concerns with using HbA1c as a surrogate outcome.

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Sitagliptin can be taken alone, or in combination with other diabetes pills such as metformin, sulfonylureas, or a TZD.

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The decrease in vitamin B 12 levels appears to be rapidly reversible with discontinuation of metformin or vitamin B 12 supplementation.

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Canagliflozin has been studied in combination with metformin alone, metformin and sulfonylurea, metformin and a thiazolidinedione (i.

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Following single and multiple oral doses of canagliflozin in patients with type 2 diabetes, dose-dependent decreases in RT G and increases in urinary glucose excretion were observed.

Furthermore, additional research is required to identify key patient and tumor factors that govern metformin sensitivity, which is critical for the design of clinical trials and the identification of patients best suited for metformin treatment.

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

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