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It is used for osteoarthritis and rheumatoid arthritis.

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For the lower extremity, the standard dosing is 4 grams applied to the affected knee, ankle, or foot four times daily.

The use of aspirin in patients with aspirin-sensitive asthma has been associated with severe bronchospasm which can be fatal.

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Thus, nonselective COX inhibition with agents such as aspirin, ibuprofen, indomethacin and naproxen, which inhibit both COX-1 and COX-2 enzymes, provides effective pain relief for inflammatory conditions but carries with it a risk of erosive gastritis and GI bleeding.

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We studied patients who used NSAIDs for arthritis and who presented with ulcer bleeding.

Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occur in approximately 1% of patients treated for 3 to 6 months, and in about 2% to 4% of patients treated for one year.

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DMSO, ethanol, propylene glycol, glycerine, and water (sometimes referred to herein as “Pennsaid”), said information comprising one or more of the following: (1) clinical effects of topical diclofenac dosing, including, for example, (a) the effects of particular four times per day (“QID”) dosing; (b) the effects of QID dosing in one or more clinical trials; © results from a 12-week, double-blind controlled trial of topical diclofenac in a solution containing dimethyl sulfoxide in subjects with osteoarthritis of the knee which compared the performance of said topical diclofenac solution against a vehicle solution containing 45.

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