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I was diagosed with inoperable NSCLC in March 11. I am taking Iressa as a first line treatment. I had no side effects for 2 weeks then the rash on my face started. I am female so was able to cover this with makeup. My skin became very dry too but moisturizers helped. I had tummy cramps which started at the same time, no diarrhea initially as I was still taking morphine from unsuccessful surgery. After 6 weeks I had my first scan. My tumor that had been 11cms was now 8.5cms, this was a pleasant surprise as I was told the Iressa would not shrink it but just stop it from growing. Since stopping the morphine I now suffer from tummy cramps and diarrhea most days, usually at night. I feel it is a small price to pay. I take Imodium which helps.

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In a phase III study of 610 patients, treatment with a combination of cisplatin, etoposide, and radiation conferred significant overall survival.

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Phase I and pharmacokinetic study of gefitinib and S-1 combination therapy for advanced adenocarcinoma of the lung.

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To confirm that T790M is present in only one of the two groups of resistant clones, we did a PCR reaction to specifically amplify exon 20, which contains codon 790, and we subsequently sequenced individual clones.

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Furthermore, a randomized phase II trial evaluating the combination of erlotinib with entinostat, a kind of oral HDAC inhibitor, in advanced NSCLC patients who failed in prior chemotherapy have completed with acceptable adverse events and prolonged OS (9.

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